Long-chain triglycerides improve recovery from myocardial stunning in conscious dogs
نویسندگان
چکیده
منابع مشابه
Long-chain triglycerides improve recovery from myocardial stunning in conscious dogs.
OBJECTIVES Free fatty acid (FFA) oxidation is depressed in the postischaemic stunned myocardium and recovers in parallel with the normalization of contractile performance. Assuming a causal role for this metabolic disturbance in the pathogenesis of stunning, we questioned whether exogenous administration of high dose triglycerides during reperfusion of postischaemic myocardium, could improve it...
متن کاملMyocardial Stunning in Dogs
This study was undertaken to elucidate whether cal-adrenoceptor activity is beneficial to contractile dysfunction during reperfusion after a brief period of ischemia (stunned myocardium) in 54 open-chest dogs. Contractile dysfunction assessed by fractional shortening (FS) was observed 3 hours after the onset of reperfusion following 15 minutes of complete occlusion of the left anterior descendi...
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UNLABELLED Chronic ingestion of small doses of ethanol protects the myocardium from ischemic damage. It was demonstrated that short-term administration of ethanol (SAE) enhances the recovery of stunned myocardium in acutely instrumented, anesthetized dogs. It is unclear whether this beneficial effect of SAE also occurs in awake dogs. Therefore, we investigated the effects of SAE on regional myo...
متن کاملBiochemical mechanism(s) of stunning in conscious dogs.
The mechanism(s) underlying contractile dysfunction in cardiac stunning is not completely understood. The expression and/or the phosphorylation state of cardiac Ca(2+) homoeostasis-regulating proteins might be altered in stunning. We tested this hypothesis in a well-characterized model of stunning. Conscious dogs were chronically instrumented, and the left anterior descending artery (LAD) was o...
متن کاملInhibition of endothelium-derived relaxing factor enhances myocardial stunning in conscious dogs.
BACKGROUND Impaired endothelial-dependent vascular responses after coronary artery occlusion (CAO) and reperfusion (CAR) have been investigated extensively. However, it is not known whether impaired endogenous endothelium-derived relaxing factor production affects postischemic myocardial dysfunction, ie, myocardial stunning. METHODS AND RESULTS Eight dogs were instrumented with an intracorona...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 1996
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(96)00165-4